Hisar, Haryana – A significant study led by Kirti Bamel, an MSc Bioinformatics student from Bhatol Jattan village, Hisar district, Haryana, is bringing crucial attention to the often-under-recognised connection between Traumatic Brain Injury (TBI) and Alzheimer’s disease (AD). Kirti’s research, conducted under the guidance of Dr. Anil Panwar at CCS Haryana Agricultural University, aims to spread awareness about these progressive neurodegenerative disorders.
Her article highlights TBI as a critical yet under-recognized risk factor for Alzheimer’s disease, contributing to long-term cognitive decline. The mechanisms identified include oxidative stress, the build-up of amyloid plaques, and tau tangles. Furthermore, post-injury neuroinflammation and dysfunction of the blood-brain barrier (BBB) are highlighted as playing central roles in accelerating neurodegeneration and increasing vulnerability to dementia. The research also points out that pathological proteins typical of AD, such as amyloid-beta and tau, are also present in post-TBI brains, suggesting shared disease pathways.
With over 55 million people globally living with dementia in 2019, a number projected to rise to 152.8 million by 2050, Alzheimer’s is a growing public health concern. In India alone, approximately 3.69 million individuals were living with Alzheimer’s or other dementias in 2019, with a major increase expected due to the rapidly aging population.
Kirti’s work underscores the vital role of bioinformatics and omics-based approaches in identifying key genes, biomarkers, and molecular signatures linking TBI to neurodegeneration. Advanced tools like artificial intelligence and machine learning models are being utilised to analyse large datasets, predict disease progression, and improve early diagnosis of TBI-related disorders. This integrative research, combining clinical studies, computational biology, and systems-level approaches, is essential for improving care and outcomes for individuals at risk of TBI-induced dementia.
The full published article can be accessed at the following link: Bioinformatics has become an essential field of interest for examining intricate biological data and revealing the possible mechanisms that have significance https://www.sciencedirect.com/science/article/pii/S2666459325000526